Holocaust victims were people targeted by the government of Nazi Germany based on their ethnicity, religion, political beliefs, and/or sexual orientation. The institutionalized practice by the Nazis of singling out and persecuting people resulted in the Holocaust, which began with legalized social discrimination against specific groups, involuntary hospitalization, euthanasia, and forced sterilization of persons considered physically or mentally unfit for society. The vast majority of the Nazi regime's victims were Jews, Sinti-Roma peoples, and Slavs but victims also encompassed people identified as social outsiders in the Nazi worldview, such as homosexuals, and political enemies. Nazi persecution escalated during World War II and included: non-judicial incarceration, confiscation of property, forced labor, sexual slavery, death through overwork, human experimentation, undernourishment, and execution through a variety of methods. For specified groups like the Jews, genocide was the Nazis' primary goal.

According to the United States Holocaust Memorial Museum (USHMM), the Holocaust was "the systematic, bureaucratic, state-sponsored persecution and murder of six million Jewish men, women and children by the Nazi regime and its collaborators". In addition, 11 million members of other groups were murdered during the "era of the Holocaust".